Abstract COVID-19, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), represents a global crisis. Key to SARS-CoV-2 therapeutic development is unraveling the mechanisms driving high infectivity, broad tissue tropism and severe pathology. Our 2.85 Å cryo-EM structure of SARS-CoV-2 spike (S) glycoprotein reveals that the receptor binding domains (RBDs) tightly bind the essential free fatty acid
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Since the beginning of the COVID-19 pandemic, laboratories have been using nucleic acid amplification tests (NAATs), such as real time reverse transcription polymerase chain reaction (rRT-PCR) assays, to detect SARS-CoV-2, the virus that causes the disease. In many countries, access to this form of testing has been challenging. The search is on to develop reliable
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Washington, DC, September 10, 2020 (PAHO) – The Pan American Health Organization (PAHO) today warned that the COVID-19 pandemic may exacerbate suicide risk factors, urging people to speak about the issue in an open and responsible manner, remain connected even during physical distancing, and learn to identify warning signs to prevent it. Coronavirus is affecting
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Washington, D.C., August 28, 2020 (PAHO) — The Director of the Pan American Health Organization (PAHO), Carissa F. Etienne, yesterday invited the PROSUR block of South American presidents to work together on access to vaccines for COVID-19. “We believe that your support and participation in the COVAX Initiative will provide the best opportunity to fast
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SARS-COV-2 is an RNA virus from the coronavirus family, the causative agent of COVID-19. With nearly 6,000,000 cases worldwide, 365,000 deaths and detection in at least well over 200 countries, it continues to evolve with devastating medical and socio-economic sequelae. The challenge with this virus is that the global population has no underlying immunity since
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Countries seek innovative ways to mitigate the impact of disruptions and keep services going. Seventy-three countries have warned that they are at risk of stock-outs of antiretroviral (ARV) medicines as a result of the COVID-19 pandemic, according to a new WHO survey conducted ahead of the International AIDS Society’s biannual conference. Twenty-four countries reported having
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On World Diabetes Day 2019, PAHO/WHO joins partners around the world to promote that diabetes can be prevented and controlled. The theme for this year is “Family and Diabetes”. Approximately 62 million people are living with type 2 diabetes in the Americas, and need support from their families. Many people with type 2 diabetes do
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June 11 2019: – Citizens of Trinidad and Tobago and the business community will soon receive improved outputs from at least two (2) local public labs with the commencement of a national accreditation programme. The activity which is being implemented by the Ministry of Trade and Industry through the Trinidad and Tobago Bureau of Standards
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The World Health Organization (WHO) published two lists that are critical for global health: the 21st WHO Model List of Essential Medicines (EML), and the 2nd WHO Model List of Essential Diagnostics (EDL). The purpose of these lists is to help countries prioritize critical health products that should be widely available, accessible, and affordable throughout
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